A Promethease alternative that speaks plain language.
Promethease is the research veteran: it matches your file against SNPedia and returns thousands of entries, though in 2026 it has grown unreliable. Helisoma takes the opposite approach: a curated set of replicated findings, written in plain words, parsed in your browser so the raw file never leaves your device.
What Promethease does well
Depth. On paper, Promethease is still the deepest read a chip file can get: it is built on SNPedia, a community-maintained wiki of published SNP research, and it reports on a huge number of variants for $25. If you enjoy reading research-grade material and drawing your own conclusions, it is a genuinely powerful tool when it delivers.
Is Promethease still working in 2026?
It depends who you ask. The site is still online, still takes $25 payments, and has posted no shutdown notice. But user communities have spent recent months reporting reports that fail to generate, disappear after purchase, or render as gibberish, and the site itself has barely changed in years. When it works, nothing matches its breadth. Whether it works has become the question, so if you try it, treat the $25 as a gamble rather than a purchase.
Where Helisoma is different
| Promethease | Helisoma | |
|---|---|---|
| Your raw DNA file | Uploaded to their servers for processing | Read in your browser, never uploaded |
| Findings style | Thousands of raw SNPedia entries to sift yourself | A curated set of replicated findings, each stating its effect size honestly |
| Reading level | Research-grade, magnitude scores and wiki excerpts | Plain language, the gene glossed in words a non-biologist understands |
| Reliability in 2026 | Site up, but users report failed and garbled reports | Actively maintained, and the free analysis shows real results before you pay |
| Works with your AI | No pairing with outside assistants | Connects to Claude live, pairs with ChatGPT, Gemini, and Whoop Coach |
| Pricing | $25 per report | $49 once, free analysis first, no subscription |
Which one should you pick?
Pick Promethease if you want maximum breadth, you are comfortable reading SNPedia-style research entries and judging the evidence yourself, and you accept the real chance the report never generates.
Pick Helisoma if you want the findings that actually replicate, explained in plain words, with your raw file staying on your device, and a report your AI assistant can read.
Also comparing? We also compare against SelfDecode and Genomelink.
Questions people ask
Is Promethease shutting down?
There is no official shutdown notice as of August 2026, and the site still sells $25 reports. But user communities widely report reports failing to generate, disappearing, or rendering as gibberish, and the site has barely changed in years. Nobody outside the company knows its plans, so if you buy a report, do it knowing it may not arrive.
Do I have to upload my raw DNA file to Helisoma?
No, and that is the core difference. Your browser reads the file on your own device and sends only the small set of markers the report uses. We never receive or store the raw file.
What does the Helisoma report cover?
Sleep and chronotype, caffeine response, nutrition markers, training and recovery, stress and mood leans, and longevity markers. Every card shows your genotype, the honest effect size, and a link to the study behind it.
How much does Helisoma cost?
The analysis is free: drop your raw DNA file on helisoma.com and see real insights with no account. The full report is a one-time $49 payment with no subscription.
Is Helisoma a medical test?
No. It is an educational wellness report built on peer-reviewed population research, not a diagnosis. Clinical questions belong with a doctor.
Guides from the blog
All articles →Curious what your DNA says?
Your browser reads your raw DNA file right on your device, so the file itself never leaves it. Out comes a personalized report you can read yourself or hand to your AI.
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